Mark T Gladwin Selected Research

Pulmonary Hypertension

12/2021	Exercise-induced changes of vital signs in adults with sickle cell disease.
1/2021	Metabolic Syndrome Mediates ROS-miR-193b-NFYA-Dependent Downregulation of Soluble Guanylate Cyclase and Contributes to Exercise-Induced Pulmonary Hypertension in Heart Failure With Preserved Ejection Fraction.
1/2021	Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.
1/2021	Mechanistic insights into cell-free hemoglobin-induced injury during septic shock.
8/2020	The Effects of Inhaled Sodium Nitrite on Pulmonary Vascular Impedance in Patients With Pulmonary Hypertension Associated with Heart Failure With Preserved Ejection Fraction.
1/2020	Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction.
12/2019	Smooth muscle cytochrome b5 reductase 3 deficiency accelerates pulmonary hypertension development in sickle cell mice.
2/2019	AMP Kinase Activation Attenuates Cardiac Remodeling in Pulmonary Hypertension due to Heart Failure with Preserved Ejection Fraction; Lung Epithelial Progenitor Cells in Alveolar Regeneration; and Drug Discovery and Novel Therapies for Lung Cancer.
7/2018	Experimental intravascular hemolysis induces hemodynamic and pathological pulmonary hypertension: association with accelerated purine metabolism.
1/2018	Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension.

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Mark T Gladwin Research Topics

Disease

94	Sickle Cell Anemia (Hemoglobin S Disease) 03/2024 - 02/2002
87	Hemolysis 02/2024 - 12/2002
70	Pulmonary Hypertension 12/2021 - 07/2003
40	Hypoxia (Hypoxemia) 05/2022 - 12/2003
19	Pulmonary Arterial Hypertension 05/2022 - 09/2007
19	Ischemia 01/2021 - 05/2005
17	Reperfusion Injury 01/2022 - 07/2004
14	Inflammation (Inflammations) 01/2022 - 03/2003
12	Heart Failure 12/2023 - 01/2015
11	Pain (Aches) 03/2024 - 07/2006
11	Hypertension (High Blood Pressure) 03/2024 - 02/2004
11	Tricuspid Valve Insufficiency (Insufficiency, Tricuspid Valve) 01/2020 - 11/2009
11	Hemolytic Anemia 01/2020 - 07/2003
9	Infarction (Infarctions) 12/2020 - 05/2005
8	Infections 03/2024 - 02/2013
8	Thalassemia 03/2023 - 01/2008
7	Lung Injury 01/2022 - 02/2014
6	Pneumonia (Pneumonitis) 03/2024 - 07/2013
6	Poisoning 08/2023 - 12/2016
6	Malaria 01/2021 - 09/2010
6	Vascular Diseases (Vascular Disease) 01/2021 - 01/2003
6	Anemia 11/2020 - 03/2005
6	Vascular System Injuries 07/2011 - 03/2003
5	Glucosephosphate Dehydrogenase Deficiency 03/2024 - 07/2010
5	Hypertrophy 05/2022 - 01/2010
5	Stroke (Strokes) 05/2022 - 02/2008
5	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2021 - 07/2015
5	Acute Chest Syndrome 01/2020 - 03/2003
5	Thrombosis (Thrombus) 01/2020 - 01/2006
5	Disease Progression 01/2018 - 11/2009
5	Myocardial Infarction 07/2008 - 05/2005
4	Proteinuria 03/2024 - 01/2014
4	Carbon Monoxide Poisoning (Poisoning, Carbon Monoxide) 08/2023 - 12/2016
4	Shock 01/2021 - 05/2005
4	COVID-19 12/2020 - 01/2020
4	Insulin Resistance 01/2020 - 07/2015
4	Dehydration (Water Stress) 12/2019 - 10/2015
4	Left Ventricular Dysfunction 01/2019 - 11/2009
4	Cardiovascular Diseases (Cardiovascular Disease) 01/2019 - 01/2011
4	alpha-Thalassemia 04/2017 - 05/2008
4	Priapism 03/2017 - 03/2006
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2014 - 07/2006
4	Hemoglobinopathies 04/2012 - 04/2005
3	Sepsis (Septicemia) 01/2021 - 01/2018
3	Heart Arrest (Cardiac Arrest) 01/2021 - 09/2009
3	Hyperglycemia 01/2020 - 02/2016
3	Pulmonary Embolism 11/2019 - 12/2006
3	Lung Diseases (Lung Disease) 01/2018 - 06/2007
3	Acute Lung Injury 03/2017 - 12/2002
3	Chronic Renal Insufficiency 03/2017 - 03/2014

Drug/Important Bio-Agent (IBA)

72	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2024 - 02/2002
69	Hemoglobins (Hemoglobin)IBA 11/2022 - 12/2002
57	NitritesIBA 12/2023 - 12/2003
21	Sickle HemoglobinIBA 02/2023 - 09/2002
21	Hydroxyurea (Hydrea)FDA LinkGeneric 02/2023 - 02/2002
19	Oxygen (Dioxygen)IBA 11/2022 - 09/2003
15	IronIBA 01/2021 - 05/2005
14	Reactive Oxygen Species (Oxygen Radicals)IBA 03/2024 - 01/2005
14	Arginine (L-Arginine)FDA Link 12/2023 - 07/2003
13	Sodium NitriteIBA 08/2020 - 03/2004
12	Biomarkers (Surrogate Marker)IBA 01/2020 - 03/2006
12	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2017 - 02/2004
11	Heme (Haem)IBA 08/2023 - 07/2004
11	Sildenafil Citrate (Viagra)FDA Link 12/2021 - 08/2005
10	NitratesIBA 12/2019 - 12/2005
10	Fetal Hemoglobin (Hemoglobin F)IBA 04/2017 - 01/2003
8	AnionsIBA 05/2013 - 01/2004
7	BilirubinIBA 11/2022 - 03/2006
7	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2021 - 07/2006
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2004
7	ArginaseIBA 01/2019 - 03/2005
7	pro-brain natriuretic peptide (1-76)IBA 01/2015 - 07/2006
6	Carbon MonoxideIBA 08/2023 - 10/2007
6	Nitric Oxide Synthase (NO Synthase)IBA 01/2014 - 01/2003
6	Vasodilator Agents (Vasodilators)IBA 02/2011 - 10/2004
5	EnzymesIBA 01/2021 - 01/2006
5	GlobinsIBA 12/2017 - 08/2009
5	Nitrite Reductases (Nitrite Reductase)IBA 04/2011 - 01/2006
4	glucose-6-phosphate dehydrogenase A-IBA 03/2024 - 01/2020
4	NeuroglobinIBA 11/2022 - 12/2011
4	Semaxinib (SU5416)IBA 05/2022 - 02/2016
4	Epoprostenol (Prostacyclin)FDA LinkGeneric 05/2022 - 01/2010
4	Oxidants (Oxidizing Agents)IBA 11/2020 - 12/2002
4	LigandsIBA 01/2020 - 08/2011
4	Metformin (Glucophage)FDA LinkGeneric 01/2020 - 02/2016
4	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 12/2011
4	Oxidoreductases (Dehydrogenase)IBA 12/2019 - 05/2008
4	Ferritins (Ferritin)IBA 01/2019 - 08/2011
4	HaptoglobinsIBA 01/2018 - 03/2006
4	Erythropoietin FDA Link 10/2016 - 08/2006
4	Superoxides (Superoxide)IBA 12/2014 - 03/2003
4	MyoglobinIBA 07/2012 - 07/2007
3	CreatinineIBA 12/2023 - 01/2008
3	AntioxidantsIBA 01/2021 - 07/2004
3	Heme Oxygenase-1IBA 01/2021 - 07/2004
3	Soluble Guanylyl CyclaseIBA 01/2021 - 08/2012
3	Leptin ReceptorsIBA 01/2021 - 02/2016

Therapy/Procedure

70	Therapeutics 03/2024 - 02/2002
3	Precision Medicine 01/2021 - 01/2020
3	Cardiopulmonary Bypass (Heart-Lung Bypass) 11/2018 - 03/2004